High-dose chemotherapy for recurrent medulloblastoma
نویسندگان
چکیده
منابع مشابه
High-dose chemotherapy for recurrent medulloblastoma: time for a reappraisal.
M ore than a decade ago, Finlay et al. published a landmark article in which they demonstrated that a subset of patients with recurrent brain tumors of diverse histologic diagnosis could be salvaged with high-dose chemotherapy followed by autologous stem cell rescue. The preparatory regimen included only 2 drugs: thiotepa and etoposide. Hematopoietic growth factors were used to enhance count re...
متن کاملChemotherapy dose-intensity and survival for childhood medulloblastoma.
AIM To determine the relationship between prescribed dose-intensity of chemotherapy and survival in childhood medulloblastoma. MATERIALS AND METHODS A total of 55 trials from 1970-2009 were identified, 30 were eligible for analysis, with individual treatment regimes with 5-year (or more) outcome figures. Relationships of outcome to dose-intensity were analysed using weighted regression. RES...
متن کاملPre-irradiation chemotherapy in high risk medulloblastoma.
RATIONALE The present study evaluates the effect of pre-irradiation chemotherapy in pediatric patients with high risk medulloblastoma. Twenty-four (24) pediatric patients attended the pediatric unit of Kasr-El-Aini Center of Radiation Oncology and Nuclear Medicine (NEMROCK) from January 2000 to January 2003. PATIENTS AND METHODS Our patients were 13 boys and 11 girls aged 3-12 years with a me...
متن کاملHIGH-DOSE ORAL PYRIDOXINE FOR TREATMENT OF PEDIATRIC RECURRENT INTRACTABLE SEIZURES
Intractable epilepsy is a common clinical problem in pediatrics and approximately 13% of children with epilepsy experience intractable seizures. To determine the efficacy of pyridoxine in treating seizures, 30 infants and children with recurrent seizures were enrolled in the present study. All of them were treated with high-dose oral pyridoxine (40 mg/kg/day), as an adjunct to antiepileptic...
متن کاملHigh-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors.
BACKGROUND High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies. METHODS To evaluate the efficacy and toxicities of HDCT and ASCR, the medical records of 27 children with recurrent CNS malignancies who received such therapy at St. Jude Children's Research Hospital b...
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ژورنال
عنوان ژورنال: Cancer
سال: 2008
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.23352